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New Horizons for Diagnostic Applications of Circulating Nucleosomes in Blood?
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Clinical Chemistry
- Article date:
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July 1, 2008
- Author:
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Copyright informationCopyright American Association for Clinical Chemistry Jul 2008. Provided by ProQuest LLC. (Hide copyright information)
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In 1974, Kornberg proposed a model of the organization of human chromatin as a nucleosomal chain formed by repeating histone-DNA sequences (1). Subsequent x-ray crystallographic analyses have confirmed his electron microscopy findings as advances in methodology and crystallographic resolution have revealed more and more details of the structure of nucleosomal core particles (2). Today, it is clear that nucleosomes consist of a central protein core of the doubly represented histones H2A-H2B and H3-H4 plus 147 bp of double-stranded DNA twisted around this complex (2, 3). Another histone, Hl, is located outside the nucleosomes at the so-called linker DNA, which connects the various 206-kDa ...
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