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Estimating Glomerular Filtration Rate in Black South Africans by Use of the Modification of Diet in Renal Disease and Cockcroft-Gault Equations
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Clinical Chemistry
- Article date:
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July 1, 2008
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Copyright informationCopyright American Association for Clinical Chemistry Jul 2008. Provided by ProQuest LLC. (Hide copyright information)
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BACKGROUND: The 4-variable Modification of Diet in Renal Disease (4-v MDRD) and Cockcroft-Gault (CG) equations are commonly used for estimating glomerular filtration rate (GFR); however, neither of these equations has been validated in an indigenous African population. The aim of this study was to evaluate the performance of the 4-v MDRD and CG equations for estimating GFR in black South Africans against measured GFR and to assess the appropriateness for the local population of the ethnicity factor established for African Americans in the 4-v MDRD equation.
METHODS: We enrolled 100 patients in the study. The plasma clearance of chromium-51-EDTA (^sup 51^CrEDTA) was used to measure GFR, and ...
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