|
|
Article: Celiac Disease and IgA Deficiency: Complications of Serological Testing Approaches Encountered in the Clinic
- Article from:
- Clinical Chemistry
- Article date:
- July 1, 2008
- Author:
CopyrightCopyright American Association for Clinical Chemistry Jul 2008. Provided by ProQuest LLC. (Hide copyright information)
|
BACKGROUND: IgA deficiency causes false-negative IgAbased celiac serology results in patients with celiac disease. Using a case-finding strategy, we examined the prevalence of IgA deficiency, physician evaluation, and management of IgA deficiency during serological testing for celiac disease.
METHODS: We reviewed consecutive IgA-endomysial antibody (EMA) and serum IgA results from the laboratory database over 17 months. We cross-referenced seronegative patients with IgA deficiency (IgA <0.06 g/L) to the pathology database to evaluate intestinal biopsy results. Ordering physicians received a questionnaire regarding the management of seronegative patients with IgA deficiency who had no ...