Article: Cavity-Creating Mutations in Pseudomonas aeruginosa Azurin: Effects on Protein Dynamics and Stability

Article: Binding of the general anesthetics chloroform and 2,2,2-trichloroethanol to the hydrophobic core of a four-alpha-helix bundle protein
Photochemistry and Photobiology;  January 1, 2003 ;     700+ words ......and 2,2,2-Trichloroethanol to the Hydrophobic Core of a Four-alpha-Helix Bundle Protein...four-alpha-helix bundle scaffold with a hydrophobic core. Previous work suggested that halothane...1) introducing a cavity into the hydrophobic core and (2) substituting a methionine...

Article: New biophysics findings from D.J. Ma and co-authors described.
Physics Week;  August 11, 2008 ;     494 words ......stacking of F12 and W15 along the long hydrophobic core and by a nearly perfect stretch of...phase to the center of the designed hydrophobic core. The site of the L38M mutation, which...similar to 3.5-fold, is not part of the hydrophobic core presumably involved in the anesthetic...

Article: New physical chemistry findings from K. Berka and co-authors described.
Chemicals & Chemistry;  May 1, 2009 ;     304 words ......study from Prague, Czech Republic, The hydrophobic core of globular proteins is responsible...energy between the amino acids of the hydrophobic core of the small globular protein rubredoxin...of Energy Stabilization inside the Hydrophobic Core of Rubredoxin. Chemphyschem, 2009...

Article: Data on DNA research reported by M. Dhanasekaran and co-researchers.(Report)
Biotech Week;  January 7, 2009 ;     425 words ......involved in the formation of the minimal hydrophobic core. However, no systematic study on the precise role of the Leu residue in the hydrophobic core formation and DNA binding function...differences in the stability of the hydrophobic core between the Val and Aib mutants, wrote...

Article: Scientists at University of Cambridge publish research in nanotechnology.
Journal of Engineering;  September 24, 2008 ;     281 words ......mechanical strength by replacing the hydrophobic core with the core of a homologous 'strong...reverse of one described earlier. The hydrophobic core of a 'weak' domain (FNfn10) was grafted...assumed to reflect properties of the hydrophobic core. Ng and colleagues published their...

Article: Data from T.X. Cui et al provide new insights into biophysics.(Report)
Physics Week;  August 11, 2008 ;     438 words ......2), was designed to contain a long hydrophobic core, enclosed by four amphipathic a-helices...pathway from the aqueous phase to the hydrophobic core, scientists in the United States report...the lateral access pathway to the hydrophobic core. Quantitative dynamics analyses, ...

Article: Understanding (beta)-hairpin formation by molecular dynamics simulations of unfolding
Biophysical Journal;  November 1, 2001 ;     700+ words ......the folded state and the hydrophobic core state. The van der Waals...energies of the residues in the hydrophobic core reflect the behavior of...with the disruption of the hydrophobic core of a protein. The results...

Article: Researchers evaluate structural consequences of BRCA1-BRCT missense mutation.(breast cancer)(Brief Article)
Cancer Weekly;  March 25, 2003 ;     315 words ......that the mutated side chain is extruded from the protein hydrophobic core, thereby altering the protein surface, stated R.S. Williams...concluded: Charge-charge repulsion, rearrangement of the hydrophobic core, and disruption of the native hydrogen bonding network...

Article: Research reports on biophysics from S. Minakata and colleagues provide new insights.
Physics Week;  September 23, 2008 ;     433 words ......of increased separation, around Glu-218 and Gln-263, the hydrophobic core is disrupted by three holes. Moreover, for the first time...tropomyosin C-terminal fragment 176-273: Exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule. Biophysical...

Article: Pressure Denaturation of Staphylococcal Nuclease Studied by Neutron Small-Angle Scattering and Molecular Simulation
Biophysical Journal;  November 1, 2004 ;     700+ words ......in which water penetration into the hydrophobic core plays a central role. INTRODUCTION...threedimensional structures with a closed-packed hydrophobic core (Kauzmann, 1959; Dill, 1990). Although...three-dimensional structures, formation of this hydrophobic core is thought to play a ...

Article: Interaction of the Antimicrobial Peptide Cyclo(RRWWRF) with Membranes by Molecular Dynamics Simulations
Biophysical Journal;  October 1, 2005 ;     700+ words ......molecules can reach deeper into the hydrophobic core, and the water penetration free-energy...We suggest that the changes in the hydrophobic core, together with the changes in the...turned out to be half buried in the hydrophobic core with the peptide backbone plane parallel...

Article: Reports from E. Gabellieri and colleagues advance knowledge in biophysics.
Physics Week;  September 23, 2008 ;     303 words ......emission of Trp-48, which was deeply buried in the compact hydrophobic core of the macromolecule, and by measurements of guanidinum...Ala introduced cavities at different distances from the hydrophobic core. The phosphorescence lifetime (tau(0)) of Trp-48, buried...

Article: SGTx1, a Kv Channel Gating-Modifier Toxin, Binds to the Interfacial Region of Lipid Bilayers
Biophysical Journal;  January 1, 2007 ;     700+ words ......toxin completely buried within the hydrophobic core of the bilayer (z = 0 and 3 [Angstrom...locations with the toxin spanning the hydrophobic core and the headgroup/ water interface...hydrophobic half was exposed to the hydrophobic core of the membrane. CG approaches offer...

Article: An Isothermal Titration Calorimetry Study on the Binding of Four Volatile General Anesthetics to the Hydrophobic Core of a Four-[alpha]-Helix Bundle Protein
Biophysical Journal;  November 1, 2003 ;     700+ words ......halothane and chloroform bind to the hydrophobic core of the four-[alpha]-helix bundle...and enflurane are also bound to the hydrophobic core of the four-[alpha]-helix bundle...respectively. The results indicate that the hydrophobic core of (A[alpha]^sub 2^-L38M)^sub 2^ is...