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A386G transition in DAZL gene is not associated with spermatogenic failure in Tamil Nadu, South India
- Article from:
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Indian Journal of Human Genetics
- Article date:
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January 1, 2008
- Author:
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Copyright informationCopyright Medknow Publications 2008. Provided by ProQuest LLC. (Hide copyright information)
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Introduction
Infertility is a major health problem today, affecting ~10-15% of married couples. Male infertility accounts for ~50% of the cases, with quantitative or qualitative abnormalities of sperm production leading to spermatogenic failure. Genetic abnormalities, as well as numerical and structural chromosomal abnormalities, have been identified in men with unexplained oligozoospermia (1-20 x 10 6 spermatozoa / ml) and azoospermia (no sperms in the ejaculate). [1] However, recent evidence suggests that a variety of newly discovered genetic causes may be associated with idiopathic infertility.
The DAZ gene family is located in the distal euchromatic part of the long arm of the human Y ...