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Can novel Apo A-I polymorphisms be responsible for low HDL in South Asian immigrants?

Introduction

Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the world. Even though rates have decreased in the United States (US) and other developed countries over the past 30 years, event rates are still high in South Asians, [1] people with ancestors from the Indian subcontinent (i.e., India, Pakistan, Bangladesh, Nepal, Bhutan, and Sri Lanka). CAD risk factors are observed in South Asians at a younger age, predisposing them to a higher risk for CAD than other populations. [2],[3],[4] Though, South Asians are the second fastest growing Asian immigrant group in the US, the causes of the increased risk of CAD remains unclear. [1]

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