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Article: Exposure to 200 PPM of methanol increases the concentrations of interleukin-1(beta) and interleukin-8 in nasal secretions of healthy volunteers
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- July 1, 2002
- Author:
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Copyright informationCopyright Annals Publishing Company Jul 2002. Provided by ProQuest LLC. (Hide copyright information)
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This study was designed to investigate subclinical irritating effects of methanol on functional and immunologic parameters in human respiratory epithelia. Twelve healthy, nonsmoking individuals were exposed to concentrations of 20 and 200 ppm of methanol in an exposure chamber. The concentrations of interleukin (IL)-8, IL-1beta, IL-6, and prostaglandin E2 (PGE2) were monitored. The saccharin transport time test was used to evaluate mucociliary transport. Video interference contrast microscopy was used to determine the ciliary beat frequency of nasal epithelial cells. Subjective symptoms were assessed with a questionnaire. The median concentrations of IL-8 and IL- 1beta were significantly ...
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