Article: Lansoprazole: Collagenous colitis: 9 case reports

Article from:
Reactions Weekly
Article date:
June 14, 2008
Author:
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In a retrospective case study, 9 patients were identified who developed collagenous colitis while receiving lansoprazole for a gastric ulcer (patient 1 ) or for gastrooesophageal reflux disease (patients 2-9) [see table for patient characteristics].

All patients reported chronic watery diarrhoea while receiving lansoprazole [Takepron; dosages not stated]; patients 1 and 9 also developed haematochezia. They had diffuse thickening of the collagen layer, inflammation of the lamina propria and surface epithelial damage. Colonoscopy was performed 2 weeks to 8 months after symptom onset, and ...

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