Article: Protamine sulfate: Anaphylaxis in an elderly patient: case report

Article from:
Reactions Weekly
Article date:
June 21, 2008
Author:
Copyright

A 67-year-old man experienced anaphylaxis after receiving protamine sulfate [therapeutic indication not stated].

The diabetic man had been treated with insulin suspension isophane containing 0.35-0.45mg protamine sulfate/100 units insulin, for 5 years. His wife denied any experience of anaphylaxis after receiving the drug. While undergoing coronary artery bypass surgery, he was weaned off bypass and administered an infusion of protamine sulfate [dosage not stated]. After two-thirds of the infusion had been given [time to reaction not clearly stated], he developed severe hypotension and bronchospasm.

The man was treated with vasopressors, corticosteroids and aminophylline. Bronchoscopy ...

Read all of this article with a FREE trial

Related newspaper, magazine, and journal articles:

Article: Protamine sulfate: Pulmonary vasoconstriction: ...
Reactions Weekly;  December 6, 2008 ;     692 words ... ... experienced severe pulmonary vasoconstriction while receiving protamine sulfate to reverse heparin effects. The man underwent coronary ... after establishing haemodynamical stability, diluted IV protamine sulfate 4 mg/kg was infused over 10 minutes. Within 10 minutes ...

Protamine Sulfate, Injection Patient Medication Advisory.
Clinical Reference Systems;  December 1, 1997 ;     610 words ...Protamine Sulfate, Injection Patient Medication Advisory This medicine is given by injection to treat an overdose of heparin (a medicine commonly ...

Article: protamine sulfate
The Mosby Medical Encyclopedia;      210 words ...The Mosby Medical Encyclopedia 10-01-1996 protamine sulfate /pr'tumn/, a drug produced from fish sperm used to lower or reverse the effect of an overdose from a drug used to block blood ...

Article: Tender Notice: Singapore General Hospital Seeks Protamine ...
US Fed News Service, Including US State News;  June 6, 2009 ;     298 words ...Singapore, June 6 -- Singapore General Hospital said it had a requirement for protamine sulfate 50mg/5ml injection. Bidding type is an international competitive bidding. The tender notice no. is GPOR01909. The last date ...

Article: Heparin/tirofiban: Heparin-induced thrombocytopenia, and bleeding ...
Reactions Weekly;  November 29, 2008 ;     623 words ... ... stated]; tirofiban was ceased 30 minutes before the end. Protamine sulfate was used to neutralise the unfractionated heparin, after ... closed and he was transferred to the ICU, 2 hours after the protamine sulfate injection. No further bleeding occurred. Author comment ...

Article: Heparin: Haematoma and haemorrhagic shock leading to fetal death ...
Reactions Weekly;  November 1, 2008 ;     641 words ... ... haematocrit 20.4%, haemoglobin 5.6 g/dL and a platelet count of 345 000/nL. Heparin was stopped, and she received protamine sulfate, IV fluids and a blood transfusion. Fetal heart sounds stopped shortly after the onset of haemorrhagic shock and ultrasonography ...

Article: Convenient and effective method for removing fibrinogen from ...
Clinical Chemistry;  June 1, 2003 ;     700+ words ... ... poorly. Alternatively, treatment with thrombin (1) or protamine sulfate in combination with thrombin (2) has been used to remove ... To illustrate the utility of this approach, we present a case report from our laboratory. Materials and Methods Plasma aliquots ...

Article: Life-Threatening Abdominal Wall Hematoma in a Chronic Renal ...
The American Surgeon;  February 1, 2005 ;     700+ words ... ... abdominal wall hematoma after a single dose of enoxaparin. Case Report A 43-year-old female (60 kg) with a history of nondialytic ... 0.6 to 1.0 antiXa lU/mL). She received 60 mg of protamine sulfate intravenously immediately prior to surgery, and a low ...

 
 
Newsweek Harper's Magazine The Washington Post Chicago Tribune Crain's Chicago Business PRNewswire Pediatric News The Nation Advertising Age The Economist (US) A FREE trial gives you access to over 80 million articles! Access over 6,500 publications with a FREE trial!

Find articles, research, and archives