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Article: Interferon-[beta]-1a: Fulminant hepatic failure in a patient with multiple sclerosis: case report
- Article from:
- Reactions Weekly
- Article date:
- June 21, 2008
- Author:
CopyrightCopyright Wolters Kluwer Health Adis International Jun 21, 2008. Provided by ProQuest LLC. (Hide copyright information)
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A 46-year-old woman with multiple sclerosis developed fulminant hepatic failure during treatment with interferonβ-1a [dosage not clearly stated].
The woman, who had previously been treated with corticosteroids for 8 years, started receiving IM interferonβ-1a 30 µg/0.5mL once weekly. Six months later, she was diagnosed with chronic thyroiditis. After 2.5 years of interferon-β-1a therapy, she experienced a multiple sclerosis relapse and received corticosteroids with improvement. One and a half months later, after receiving her weekly interferon-β injection, she developed jaundice and confusion. She became comatose in 48 hours and required intubation. She was ...