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Article: Aluminum Exposure From Pediatric Parenteral Nutrition: Meeting the New FDA Regulation
- Article from:
- JPEN, Journal of Parenteral and Enteral Nutrition
- Article date:
- May 1, 2008
- Author:
CopyrightCopyright American Society for Parenteral and Enteral Nutrition May/Jun 2008. Provided by ProQuest LLC. (Hide copyright information)
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Background: Aluminum toxicity can cause serious central nervous system and bone toxicities. Aluminum is a contaminant of parenteral nutrition (PN) solution components. Premature neonates requiring high doses of calcium and phosphate to mineralize their bones, children with impaired renal function, and children on PN therapy for prolonged duration are at the highest risk. Effective in July 2004, the U.S. Food and Drug Administration (FDA) mandated labeling requirements for aluminum content in all PN solution components. To assess the aluminum exposure in neonatal and pediatric populations, this study aims to determine patients' daily aluminum load (µg/kg/d) delivered from PN solutions. ...