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Article: The Relationship Between Homozygosity and the Frequency of the Most Frequent Allele
- Article from:
- Genetics
- Article date:
- August 1, 2008
- Author:
CopyrightCopyright Genetics Society of America Aug 2008. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Homozygosity is a commonly used summary of allele-frequency distributions at polymorphic loci. Because high-frequency alleles contribute disproportionately to the homozygosity of a locus, it often occurs that most homozygotes are homozygous for the most frequent allele. To assess the relationship between homozygosity and the highest allele frequency at a locus, for a given homozygosity value, we determine the lower and upper bounds on the frequency of the most frequent allele. These bounds suggest tight constraints on the frequency of the most frequent allele as a function of homozygosity, differing by at most ¼ and having an average difference of .... The close connection between ...