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Article: Local Anesthetics Time-Dependently Inhibit Staphylococcus aureus Phagocytosis, Oxidative Burst and CD11b Expression by Human Neutrophils
- Article from:
- Regional Anesthesia and Pain Medicine
- Article date:
- July 1, 2008
- Author:
CopyrightCopyright Churchill Livingstone Inc., Medical Publishers Jul/Aug 2008. Provided by ProQuest LLC. (Hide copyright information)
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Background and Objectives: Local anesthetics have been shown to modulate neutrophil functions in a time-dependent manner, which might help to prevent inflammatory injury to the organism. However, if host defense mechanisms are affected similarly, the ability to eliminate bacteria might be reduced. We hypothesized that local anesthetics have time-dependent effects on phagocytosis of S. aureus, oxidative burst, and CD11b expression by human neutrophils. To test this hypothesis, we reanalyzed data from a previous study.
Methods: Blood samples from 11 healthy volunteers were incubated with lidocaine (1,846 µmol/L), bupivacaine (770 µmol/L) or ropivacaine (801 µmol/L) for 30 minutes. ...