Pharmacokinetics and Biodistribution of ^sup 111^In- and ^sup...

The Journal of Nuclear Medicine;  April 1, 2005 ;     700+ words ...^sup 111^In-Labeled antibodies and peptides have...used as chemical and biologic surrogates for ^sup 90^Y-labeled therapeutic agents. However, recent...significant differences in biodistribution between ^sup 111^In- and ^sup 90^Y-labeled agents. Yttrium...

^sup 99m^Tc-MAEC Complexes: New Renal Radiopharmaceuticals Combining...

The Journal of Nuclear Medicine;  May 1, 2004 ;     700+ words ...^sup 99m^Tc-Mercaptoacetyltriglycine (^sup 99m^Tc-MAG3) and ^sup 99m^Tc-L,L-ethylenedicysteine (^sup 99m^Tc-LL-EC) are useful renal radiopharmaceuticals; however, both agents have renal clearances less than that of ^sup 131^I-orthoiodohippurate...

Effects of Intracellular and Extracellular Concentrations of Ca^sup 2+^,...

Biophysical Journal;  July 1, 2006 ;     700+ words ...ABSTRACT Intracellular Mg^sup 2+^ concentration ([Mg^sup 2+^]^sub i^) was measured in rat ventricular myocytes with...indicator furaptra (25C). After the myocytes were loaded with Mg^sup 2+^, the initial rate of decrease in [Mg^sup 2+^]^sub i^ (initial...

Development of a Novel ^sup 99m^Tc-Chelate-Conjugated Bisphosphonate with...

The Journal of Nuclear Medicine;  December 1, 2006 ;     700+ words ...In bone scintigraphy using ^sup 99m^Tc with methylenediphosphonate (^sup 99m^Tc-MDP) and hydroxymethylenediphosphonate (^sup 99m^Tc-HMDP), it takes 2-6 h after an injection before imaging can start. This interval could be shortened with a new radiopharmaceutical...

Processing of Generator-Produced ^sup 68^Ga for Medical Application

The Journal of Nuclear Medicine;  October 1, 2007 ;     700+ words ...The ^sup 68^Ge/^sup 68^Ga generator provides an excellent source of positron-emitting ^sup 68^Ga. However, newly available "ionic" ^sup 68^Ge/^sup 68^Ga radionuclide generators are not necessarily optimized for the synthesis of ^sup 68^Ga-labeled...

Low-Affinity Na^sup +^ Uptake in the Halophyte Suaeda maritima1[C][W][OA]

Plant Physiology;  October 1, 2007 ;     700+ words ...Na^sup +^ uptake by plant roots has largely been explored using species that accumulate little Na^sup +^ into their shoots. By way of contrast, Nathe...its leaves. Here we report that cAMP and Ca^sup 2+^ (blockers of nonselective cation channels...

^sup 203^Pb-Labeled [alpha]-Melanocyte-Stimulating Hormone Peptide as an...

The Journal of Nuclear Medicine;  May 1, 2008 ;     700+ words ...Peptide-targeted α-therapy with 7.4 MBq of ^sup 212^Pb-[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-ReO-[Cys^sup 3,4,10^, D-Phe^sup 7^,Arg^sup 11^]α-MSH^sub 3-13^ (^sup 212^Pb-DOTA-Re(Arg^sup 11^)CCMSH...

^sup 99m^Tc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid...

The Journal of Nuclear Medicine;  December 1, 2004 ;     700+ words ...^sup 99m^Tc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5...myocardial uptake and clearance kinetics and organ biodistribution of ^sup 99m^Tc-N-DBODC5 with ^sup 99m^Tc-sestamibi and ^sup 99m^Tc-tetrofosmin. Methods: Seventy-five...

Comparison of ^sup 123^I and ^sup 131^I for Whole-Body Imaging in Thyroid...

The Journal of Nuclear Medicine;  May 1, 2002 ;     700+ words ...We compared the diagnostic sensitivities of ^sup 123^I and ^sup 131^I whole-body imaging in differentiated thyroid cancer...thyroidectomized patients (3 previously treated with ^sup 131^I) were studied. After a period of thyroid hormone...

Arabidopsis HMA2, a Divalent Heavy Metal-Transporting P^sub IB^-Type...

Plant Physiology;  November 1, 2004 ;     700+ words ...P^sup IB^-type ATPases transport heavy metal ions (Cu^sup +^, Cu^sup 2+^, Zn^sup 2+^, Cd^sup 2+^, Co^sup 2+^, etc.) across biological membranes. Several members of this subfamily are present in plants. Higher plants are the only eukaryotes where putative...

Skeletal PET with ^sup 18^F-Fluoride: Applying New Technology to an Old...

The Journal of Nuclear Medicine;  January 1, 2008 ;     700+ words ...Although ^sup 18^F-labeled NaF was the first widely used...fell into disuse after the introduction of ^sup 99m^Tc-labeled bone-imaging agents. Recent comparative studies have demonstrated that ^sup 18^F-fluoride PET is more accurate than ^sup...

Treatment with ^sup 177^Lu-DOTATOC of Patients with Relapse of...

The Journal of Nuclear Medicine;  August 1, 2005 ;     700+ words ...Therapy with [^sup 90^Y-DOTA^sup 0^, Tyr^sup 3^]-octreotide (DOTATOC, where DOTA = tetraazacyclododecane tetraacetic acid and TOC = D-Phe-c(Cys-Tyr-D-Trp-Lys-Thr-Cys)-Thr(ol)) is established for the treatment of metastatic neuroendocrine tumors. Nevertheless...

Differential Uptake of O-(2-^sup 18^F-Fluoroethyl)-L-Tyrosine, L-^sup...

The Journal of Nuclear Medicine;  December 1, 2007 ;     700+ words ...The amino acid O-(2-^sup 18^F-fluoroethyl)-L-tyrosine (^sup 18^F-FET) has been shown to be a useful tracer for brain tumor imaging. Experimental studies demonstrated no uptake of ^sup 18^F-FET in inflammatory cells but increased uptake has been...

Nuclear Uptake and Dosimetry of ^sup 64^Cu-Labeled Chelator-Somatostatin...

The Journal of Nuclear Medicine;  August 1, 2007 ;     700+ words ...^sup 64^Cu radiopharmaceuticals have shown tumor growth...that may be related to nuclear localization of the ^sup 64^Cu in tumor cells. Here we address whether the nuclear localization of ^sup 64^Cu from a ^sup 64^Cu-labeled chelator-somatostatin...

Comparison of ^sup 99m^Tc- and ^sup 18^F-Ubiquicidin Autoradiography to...

The Journal of Nuclear Medicine;  June 1, 2008 ;     700+ words ...^sup 99m^Tc-ubiquicidin (UBI) 29-41 is under clinical evaluation...and unspecific inflammation. We compared the distribution of ^sup 99m^Tc-UBI 29-41, the potential PET tracers ^sup 18^F-UBI 29-41 and ^sup 18^F-UBI 28-41, and ^sup 3^H-deoxyglucose...