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Androgen receptor gene CAG repeat length in women with metabolic syndrome

Abstract

Objective. The length of the androgen receptor gene CAG repeat [AR (CAG)^sub n^] modulates the activity of the androgen receptor (AR), and this polymorphism has been shown to modulate body fat mass and serum concentrations of insulin in men. We hypothesized that shorter AR (CAG)^sub n^ is associated with metabolic syndrome (MBS) or its components in women.

Design, patients and measurements. In a cross-sectional controlled study we studied 52 Finnish women aged 34-55 years with MBS and 69 age-matched controls. All participants were recruited from a sample of women drawn from the Finnish population register. We compared the mean AR (CAG)^sub n^ in the two groups. Furthermore, we ...

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