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Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndrome
- Article from:
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Gynecological Endocrinology
- Article date:
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July 1, 2008
- Author:
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Copyright informationCopyright Taylor & Francis Ltd. Jul 2008. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
Objectives. To investigate the insulin response to glucose loading and to determine which method is best in order to evaluate insulin resistance in women with polycystic ovary syndrome (PCOS).
Methods. In order to eliminate the influence of obesity on the variables, all subjects were non-obese. Standard oral glucose tolerance tests were performed in 23 normal women and 21 patients with PCOS. Insulin resistance was evaluated by the homeostasis model assessment insulin resistance index (HOMA-IR), homeostasis model assessment for β-cell function (HOMA-%B), the quantitative insulin-sensitivity check index (QUICKI) and area under the curve for glucose (AUC^sub glucose^) and insulin ...
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