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Canvassing Protein Complexes

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Two yeast studies begin to identify protein interactions on a genome-wide scale.

The drama of biology is played out through thousands of protein-protein interactions. Historically, researchers could only examine these interactions one by one, but genomic sequences and high throughput methods have opened up the "interactome" - the complete list of all protein interactions in an organism.

With a sequenced eukaryotic genome, lists of every protein, and genetic amenability, Saccharomyces cerevisiae was an obvious model with which to examine cell-wide protein interactions. In 2000, Peter Uetz and colleagues, then at the University of Washington, made the first attempt at ...

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