Magazine article from our research archive:

Mysterious resistance

HOT PAPER IN MICROBIOLOGY

The paper:

G. A. Jacoby et al. "qnrB, another plasmid-mediated gene for quinolone resistance," Antimicrob Agents Chemother, 50:1178-82, 2006. (Cited in 65 papers)

The finding:

Eight years after discovering qnrA, the first plasmid-mediated gene for resistance to the broad-spectrum antibiotic quinolone, George Jacoby of the Lahey Clinic found a second resistance gene, qnrB, isolated from strains of the bacteria Klebsiella pneumoniae. After qnrB was cloned and sequenced, a PCR assay revealed it to be as common as qnrA in samples from the United States.

The significance:

Resistance to quinolones was previously believed to require a chromosomal mutation, says John ...

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