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Mysterious resistance
- Article from:
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The Scientist
- Article date:
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September 1, 2008
- Author:
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Copyright informationCopyright The Scientist, Inc. Sep 2008. Provided by ProQuest LLC. (Hide copyright information)
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HOT PAPER IN MICROBIOLOGY
The paper:
G. A. Jacoby et al. "qnrB, another plasmid-mediated gene for quinolone resistance," Antimicrob Agents Chemother, 50:1178-82, 2006. (Cited in 65 papers)
The finding:
Eight years after discovering qnrA, the first plasmid-mediated gene for resistance to the broad-spectrum antibiotic quinolone, George Jacoby of the Lahey Clinic found a second resistance gene, qnrB, isolated from strains of the bacteria Klebsiella pneumoniae. After qnrB was cloned and sequenced, a PCR assay revealed it to be as common as qnrA in samples from the United States.
The significance:
Resistance to quinolones was previously believed to require a chromosomal mutation, says John ...