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Article: Topical dinitrochlorobenzene (DNCB) for alopecia areata: Revisited
- Article from:
- Indian Journal of Dermatology, Venereology and Leprology
- Article date:
- July 1, 2008
- Author:
CopyrightCopyright Medknow Publications Jul/Aug 2008. Provided by ProQuest LLC. (Hide copyright information)
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Sir,
Treatment of alopecia areata with topical immunotherapy by contact sensitizers is an effective and accepted therapeutic modality in the treatment of chronic severe alopecia areata. [1],[2] The contact sensitizers used in alopecia areata are dinitrochlorobenzene (DNCB), diphenyl-cyclo-propenone (DPCP) [3] and squaric acid dibutyl ester (SADBE). We used DNCB in the treatment of chronic resistant alopecia areata. [4]
DNCB powder was dissolved in acetone and diluted in appropriate concentrations of 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, 1%, 1.5% and 2% solutions. Solution was stored in dark bottles until use in room temperature. DNCB was applied using cotton buds. Sensitization was done by ...