|
|
Article: Coagulation disorders with valproic acid in children
- Article from:
- Inpharma Weekly
- Article date:
- August 23, 2008
- Author:
CopyrightCopyright Wolters Kluwer Health Adis International Aug 23, 2008. Provided by ProQuest LLC. (Hide copyright information)
|
The use of valproic acid appears to be associated with a high incidence of coagulation disorders in children with seizures or epilepsy, according to results of a longitudinal study.
In this prospective trial, 23 such patients who were newly treated with valproic acid were assessed. Blood samples were taken before treatment start, after less than 6 weeks of treatment, after 6 weeks to 6 months of therapy, then after greater than 6 months of treatment. Furthermore, 35 neurologically healthy children not receiving any drugs were included as a control group.
During the study, there were no clinical signs of bleeding or apparent signs of a coagulation disorder, and no patients developed ...