Radioligands for Brain Imaging of the [kappa]-Opioid System

The Journal of Nuclear Medicine;  March 1, 2005 ;     700+ words ...The opioid receptor system is an essential part of...documented (1,2). Understanding of opioid receptor availability and function, however...selective tracers that assess an opioid receptor subtype, in particular, κ...

Imaging [delta]- and [mu]-Opioid Receptors by PET in Lung Carcinoma...

The Journal of Nuclear Medicine;  February 1, 2007 ;     700+ words ......the presence of δ- and μ-opioid receptor types in the 3 major human lung carcinomas...biology. Key Words: PET; lung carcinoma; opioid receptor J Nucl Med 2007; 48:207-213 Lung carcinoma...show a differential distribution of opioid receptor types in lung carcinoma cells. ...

North Carolina, California Inventors Develop Cardioprotective Delta Opioid...

US Fed News Service, Including US State News;  January 4, 2008 ;     239 words ......and Peter J. Gengo of Sunnyvale, Calif., have developed opioid receptor agonists. According to the U.S. Patent & Trademark Office...for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects...

Pennsylvania Inventors Develop Opioid Receptor Modulator Compound

US Fed News Service, Including US State News;  April 18, 2007 ;     200 words ......Glenside, Pa., have developed compounds as opioid receptor modulators. According to the U.S. Patent &...invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful...

WIPO: Inventor in Oregon Develops Peripheral Opioid Receptor Antagonists

US Fed News Service, Including US State News;  November 24, 2008 ;     168 words ......Avey of Eugene, Ore., has developed the uses of peripheral opioid receptor antagonists. According to a description of the invention...invention aims to provide "compounds useful as peripheral opioid receptor antagonists, or prodrugs." The patent has been assigned...

French Inventor Develops Polypeptides with Opioid Receptor Activity

US Fed News Service, Including US State News;  November 27, 2007 ;     188 words ......Kieffer of Strasbourg, France, has developed polypeptides with opioid receptor activity. According to the U.S. Patent & Trademark Office: "The present invention concerns novel polypeptides having opioid receptor activity, the genetic material permitting their expression...

Gene variant may be key to fentanyl response: patients with the genetic...

OB GYN News;  June 1, 2005 ;     591 words ......common genetic variant on the [mu]-opioid receptor had a markedly reduced need for intrathecal...Genetic polymorphism of the [mu]-opioid receptor is very common, found in roughly 10...intrathecal fentanyl effect by [mu]-opioid receptor A118 polymorphism, said Dr. Landau...

New Jersey, Pennsylvania, Massachusetts, Illinois Inventors Develop Mu...

US Fed News Service, Including US State News;  May 30, 2007 ;     244 words ......Newton, Mass., and Zhangjie Shi of Chicago, have developed Mu opioid receptor ligands, methods of use and synthesis. According to the...horse). The compounds are useful as modulators of the mu opioid receptor through their binding affinity with that receptor." The...

Opioid Receptor PET Reveals the Psychobiologic Correlates of Reward...

The Journal of Nuclear Medicine;  August 1, 2008 ;     700+ words ......to be relevant in addiction and the opioid receptor status in healthy subjects. Methods...as a parameter of regional cerebral opioid receptor availability was computed by means...between personality dimensions and opioid receptor availability showed a significant...

The pain pipeline

Pharmaceutical Executive;  December 1, 2002 ;     700+ words ......first-- in-class approaches: kappa opioid receptor agonists for pain management and mu opioid receptor antagonists to block current opioid...belongs to the second category-opioid receptor antagonist. Its mechanism of action...

Danish, Swedish Inventors Develop Diazabicyclonane And-Decane Derivatives

US Fed News Service, Including US State News;  May 27, 2008 ;     202 words ......to "novel diazabicyclononane and -decane derivatives useful as opioid receptor ligands. More specifically, the invention provides compounds useful as micrometer opioid receptor ligands." The inventors were issued U.S. Patent No. 7,358,243...

Mixed Opioid-Mixed Message?

Anaesthesia and Intensive Care;  June 1, 2006 ;     700+ words ......more common than previously realised. Keywords: MOP-R; MOP; opioid receptor; analgesia; mu receptor CASE HISTORY The female patient...and nociccptin (NOP-R), there is evidence that additional opioid receptor phenotypes exist through post-translational modifications...

How pharmacogenomics might help addiction treatment

The Scientist;  June 1, 2007 ;     700+ words ......home she began taking naltrexone, an opioid receptor antagonist originally indicated for...Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding...functional polymorphism of the mu-opioid receptor gene is associated with naltrexone...

Comprehensive Mu-Opioid-Receptor Genotyping by Pyrosequencing

Clinical Chemistry;  March 1, 2004 ;     700+ words ...The human -opioid receptor, encoded by the OPRM1 gene (1...which codes for an Asn40Asp -opioid receptor, has been associated with decreased opioid activity in carriers of the 118G...greater cortisol response to opioid receptor blockade with naloxone (5). Regarding...OPRM1 ...

Japanese Inventors Develop Pain Treatment System

US Fed News Service, Including US State News;  August 14, 2008 ;     231 words ......Trademark Office: "The present invention relates to kappa opioid receptor agonists comprising 2-phenylbenzothiazoline derivatives...2-phenylbenzothiazoline derivatives or salts thereof. The kappa opioid receptor agonists of the present invention are particularly useful...