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Frailty and Its Potential Relevance to Cardiovascular Care

Frailty Is characterized by vulnerability to acute Stressors and Is a consequence of decline In overall function and physiologic reserves. An estimated 7% of the US population older than 65 years and 30% of octogenarians are frail. The domains to define frailty Include mobility, strength, balance, motor processing, cognition, nutrition, endurance, and physical activity. Pathophyslologlc pathways leading to frailty Involve a multisystem cascade that Includes neuroendocrine dysfunction with lower insulinlike growth factor and dehydroeplandrosterone sulfate and an altered Inflammatory milieu with Increased levels of C-reactlve protein, Inter leuklns, tumor necrosis factor α, and abnormal ...

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