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Frailty and Its Potential Relevance to Cardiovascular Care
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Mayo Clinic Proceedings
- Article date:
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October 1, 2008
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Copyright informationCopyright Mayo Foundation for Medical Education and Research Oct 2008. Provided by ProQuest LLC. (Hide copyright information)
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Frailty Is characterized by vulnerability to acute Stressors and Is a consequence of decline In overall function and physiologic reserves. An estimated 7% of the US population older than 65 years and 30% of octogenarians are frail. The domains to define frailty Include mobility, strength, balance, motor processing, cognition, nutrition, endurance, and physical activity. Pathophyslologlc pathways leading to frailty Involve a multisystem cascade that Includes neuroendocrine dysfunction with lower insulinlike growth factor and dehydroeplandrosterone sulfate and an altered Inflammatory milieu with Increased levels of C-reactlve protein, Inter leuklns, tumor necrosis factor α, and abnormal ...
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