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Low-Dose Statin Concentration in Red Yeast Rice: A Confounding Effect on Outcome?/In reply

To the Editor: The recent article by Becker et al1 reporting results from the Simvastatin vs Therapeutic Lifestyle Changes and Supplements: Randomized Primary Prevention Trial shows that patients with hyperlipidemia could benefit from lifestyle changes combined with ingestion of red yeast rice and fish oil. The significant weight difference between the 2 treatment groups-the patients in the alternative treatment group were obese and those in the simvastatin group were only overweight-is accounted for by the authors by an adjustment for baseline weight. However, even after this statistically correct adjustment, there is still the impression that the weight difference may have affected the ...

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