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Article: Hyperkeratotic spicules and papulopustular eruption: case report
- Article from:
- Reactions Weekly
- Article date:
- August 23, 2008
- Author:
CopyrightCopyright Wolters Kluwer Health Adis International Aug 23, 2008. Provided by ProQuest LLC. (Hide copyright information)
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Sorafenib
A 52-year-old man developed a severe papulopustular eruption and hyperkeratotic spicules du ring treatment with sorafenib for metastatic renal cancer.
Two months after starting treatment with sorafenib [Nexavar] 600 mg/day, the man presented with a painful papulopustular eruption of his face, scalp and neck of 4 weeks' duration, alopecia of his scalp and eyebrows, and painful bullous lesions on his palms and soles. On physical examination he had a follicular papulopustular eruption on his head and neck, with some malodorous purulent discharge from the larger lesions; there were also a few lesions in his genital area. His scalp, trunk and abdomen were covered in a diffuse eruption ...