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Oral Administration of Polyphenolic Compounds from Cognac Decreases ADP-Induced Platelet Aggregation and Reduces Chronotropic Effect of Isoprenaline in Rats
- Article from:
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Physiological Research
- Article date:
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July 1, 2008
- Author:
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Copyright informationCopyright Institute of Physiology 2008. Provided by ProQuest LLC. (Hide copyright information)
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Summary
This study sought to evaluate whether consumption of polyphenol extract from Cognac (CPC) modulates platelet activation and cardiovascular reactivity in rats. Male Wistar rats were treated daily for 4 weeks by intra-gastric gavage receiving CPC at 80 mg/kg/day or vehicle (5 % glucose). Platelet adhesion and aggregation in response to different activators were assessed. Cardiac and vascular reactivity in response to various agonists as well as NO measurement by electron paramagnetic resonance technique were investigated in isolated heart and thoracic aorta. Oral administration of CPC decreased platelet aggregation induced by ADP but not by collagen. CPC did not affect adhesion to ...
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