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The Relationship between Glycemia, Insulin and Oxidative Stress in Hereditary Hypertriglyceridemic Rat
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Physiological Research
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July 1, 2008
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Copyright informationCopyright Institute of Physiology 2008. Provided by ProQuest LLC. (Hide copyright information)
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Summary
The aim of this study was to determine the effects of insulin infusion on oxidative stress induced by acute changes in glycemia in non-stressed hereditary hypertriglyceridemic rats (hHTG) and Wistar (control) rats. Rats were treated with glucose and either insulin or normal saline infusion for 3 hours followed by 90 min of hyperglycemic (12 mmol/l) and 90 min of euglycemic (6 mmol/l) clamp. Levels of total glutathione (GSH), oxidized glutathione (GSSG) and total antioxidant capacity (AOC) were determined to assess oxidative stress. In steady states of each clamp, glucose infusion rate (GIR) was calculated for evaluation of insulin sensitivity. GIR (mg.kg^sup -1^.min^sup -1^) was ...
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