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Lidocaine Suppresses Subthreshold Oscillations by Inhibiting Persistent Na+ Current in Injured Dorsal Root Ganglion Neurons
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Physiological Research
- Article date:
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July 1, 2008
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Copyright informationCopyright Institute of Physiology 2008. Provided by ProQuest LLC. (Hide copyright information)
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Summary
The aim of this study was to determine the effect and mechanism of low concentration of lidocaine on subthreshold membrane potential oscillations (SMPO) and burst discharges in chronically compressed dorsal root ganglion (DRG) neurons. DRG neurons were isolated by enzymatic dissociation method. SMPO, burst discharges and single spike were elicited by whole cell patch-clamp technique in current clamp mode. Persistent Na+ current (I^sub NaP^) and transient Na+ current (I^sub NaT^) were elicited in voltage clamp mode. The results showed that SMPO was suppressed and burst discharges were eliminated by tetrodotoxin (TTX, 0.2 µmol/l) in current clamp mode, I^sub NaP^ was blocked by 0.2 ...
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