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Family History of Diabetes Mellitus Determines Insulin Sensitivity and [beta] Cell Function in Polycystic Ovary Syndrome

Summary

Objective: To examine the impact of family history of diabetes mellitus 2 (DM 2) on insulin sensitivity and secretion in lean women with polycystic ovary syndrome (PCOS). Thirteen healthy women (C), 14 PCOS without family history of DM 2 (FH-) and 8 PCOS with family history of DM 2 (FH+) were examined using euglycemic hyperinsulinemic clamp and an arginine secretion test (insulin and glucagon at fasting glycemia (AIR^sub FG^ and AGR^sub FG^) and at hyperglycemic (AIR^sub 14^ and AGR^sub 14^)). FH+ women were more insulin resistant than FH- with lower insulin sensitivity index corrected per lean body mass (p<0.05). They had significantly higher triglycerides (p<0.05) and lower ...

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