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Article: Impeding PD-1
- Article from:
- The Scientist
- Article date:
- October 1, 2008
- Author:
CopyrightCopyright The Scientist, Inc. Oct 2008. Provided by ProQuest LLC. (Hide copyright information)
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The discovery that blocking an inhibitory immune receptor restores T cell function in HIV sheds light on immune dysfunction.
Programmed death I (PD-1), an inhibitory receptor on immune system cells, has long been known to play an important dual role in immune regulation: Preventing the immune system from attacking the self and keeping an activated immune system in check.
In 2006, however, Rafi Ahmed, of the Emory University School of Medicine, and colleagues discovered that the PD-1 pathway could also be exploited by pathogens to repress normal T cell function during chronic viral infection. In mice infected with fymphocytic choriomeningrtis virus (LCMV), Ahmed found PD-1 ...