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Article: The effect of aqueous extract of Embelia ribes Burm on serum homocysteine, lipids and oxidative enzymes in methionine induced hyperhomocysteinemia
- Article from:
- Indian Journal of Pharmacology
- Article date:
- September 1, 2008
- Author:
CopyrightCopyright Medknow Publications Sep/Oct 2008. Provided by ProQuest LLC. (Hide copyright information)
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Introduction
Hyperhomocysteinemia is a risk factor for coronary atherosclerotic vascular disease, stroke, and venous thrombosis. It has been associated with Alzheimer's disease and vascular dementia. [1],[2],[3],[4] Although its pathophysiological mechanisms are complex and not fully understood, much evidence suggests that hyperhomocysteinemia induces vascular and brain damage because of the highly reactive thiol group in homocysteine, which is readily oxidized, leading to the formation of homocysteine, homocysteine mixed disulfides and homocysteine thiolactone. During these oxidative processes, several reactive species are generated. [2] The methionine cycle is responsible for the ...