Article: WIPO: Inventors in California Develop Holin-Enhanced Vaccines

GENEVA, Nov. 5 - Peter M. Lauer of Albany, Calif., Thomas W. Dubensky of Piedmont, Calif., William S. Luckett of Richmond, Calif., and William G. Hanson of Walnut Creek, Calif., have developed reagents to encode heterologous polypeptides.

According to an abstract posted by the World Intellectual Property Organization, the invention provides "listeria that, in addition to comprising polynucleotides that encode heterologous polypeptides such as tumor or infectious agent antigens, have been modified to express holin proteins that facilitate the delivery of the heterologous polypeptides, or polynucleotides encoding the same, outside of the bacteria."

The invention carries International ...

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