Article: Fenofibrate/rosiglitazone interaction: Decreased HDL cholesterol levels: 3 patients

Three patients developed decreased HDL cholesterol levels during concomitant treatment with rosiglitazone [therapeutic indication not clearly stated] and fenofibrate [dosages not and duration of treatment before reaction onset not stated].

A 66-year-old woman, who had type 2 diabetes mellitus, lipid metabolism disorders and coronary artery disease, was treated with rosiglitazone, metoprolol, aspirin, metformin, and fluvastatin. Metformin was increased in dosage and fenofibrate was initiated due to hypertriglyceridaemia. Subsequently, her level of HDL cholesterol decreased from 46 mg/dL to 10-15 mg/dL. Rosiglitazone was changed to pioglitazone, and her level of HDL cholesterol increased to ...

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