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Article: Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
- Article from:
- Indian Journal of Pharmacology
- Article date:
- January 1, 2008
- Author:
CopyrightCopyright Medknow Publications Jan/Feb 2008. Provided by ProQuest LLC. (Hide copyright information)
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Introduction
Being the second most common cause of death in industrial countries and one of the major causes of death and disability, stroke has a great effect on public health. Among the neurological diseases, stroke accounts for the largest number of hospitalizations. [1] A variety of mechanisms are involved in ischemic brain injury. The cascade of events leading to neuronal injury and death in ischemia includes the release of cytokines, free radicals, and platelet activation. [2] Furthermore, reactive oxygen species, including the superoxide anion, hydroxyl radical, and peroxynitrite radical, have been implicated in neuronal cell damage and death after cerebral ischemia. [3] Brain ...