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Article: Ibuprofen: Fulminant liver failure: case report
- Article from:
- Reactions Weekly
- Article date:
- November 29, 2008
- Author:
CopyrightCopyright Wolters Kluwer Health Adis International Nov 29, 2008. Provided by ProQuest LLC. (Hide copyright information)
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A 48-year-old man developed fulminant liver failure following treatment with Ibuprofen [dosage, therapeutic indication and duration of treatment to reaction onset not stated].
The man developed fulminant liver failure and underwent liver transplantation and, intraoperatively, was diagnosed with acute necrotising pancreatitis; he required orotracheal intubation. After an exhaustive study of the aetiology, ibuprofen-related drug toxicity was identified as a probable cause of his fulminant liver failure. He had grade IV encephalopathy. Laboratory investigation revealed the following: creatinine 2.7 mg/dL, prothrombin time 56% and total bilirubin level 42; he also had hypoglycaemia. After the ...