Article: Cornell scientists find key to vitamin B1 biosynthesis

Article: Study findings from Cornell University provide new insights into enzyme research.
Biotech Week;  January 21, 2009 ;     321 words ...4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase catalyzes a complex rearrangement of 5-aminoimidazole ribonucleotide (AIR) to form HMP-P, the pyrimidine moiety of thiamine phosphate...determined the three-dimensional structures of HMP-P synthase and ...

Article: New spectroscopy study findings recently were published by K. Yokoyama and co-researchers.
Medical Devices & Surgical Technology Week;  November 9, 2008 ;     377 words ...According to a study from Tokyo, Japan, BtrN is a radical SAM (S-adenosyl-L-methionine) enzyme that catalyzes the oxidation...Biochemistry (Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance...

Article: Reports on drug resistance findings from A.M.B. Giessing and co-researchers provide new insights.
Biotech Week;  March 18, 2009 ;     410 words ......The mutation of single conserved cysteine residues in the radical SAM motif CxxxCxxC of Cfr abolishes its activity, lending support...of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in...

Article: Studies from Pennsylvania State University have provided new data on enzyme research.
Biotech Week;  October 1, 2008 ;     655 words ......Ala substitutions at each of the cysteines in its CX3CX2C radical SAM motif contained 7.3 +/- 0.1 irons and 7.2 +/- 0.2 sulfides...study in Biochemistry (In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S...

Article: Report summarizes enzyme research study findings from E. Pilet and co-researchers.
Biotech Week;  April 29, 2009 ;     283 words ......SAM or AdoMet)'' iron-sulfur enzymes, HydE and HydG, and one GTPase, HydF. The sequence homology between HydG and ThiH, a Radical-SAM enzyme which cleaves tyrosine into p-cresol and dehydroglycine, and the finding of a similar cleavage reaction catalyzed by...

Article: New enzyme research study results reported from A. Chandorproust et al.
Biotech Week;  February 18, 2009 ;     360 words ......the great resistance of the spores to UV irradiation. SPL belongs to a superfamily of [4Fe-4S] iron-sulfur enzymes, called ''Radical-SAM.'' Here, we show that the single substitution of cysteine 141 into alanine, a residue fully conserved in Bacillus species...

Article: Research from Technical University yields new data on biochemistry.
Biotech Week;  September 3, 2008 ;     248 words ......Technical University. The researchers concluded: Unusual and challenging biochemistry including tRNA-dependent reactions, radical SAM enzymes and substrate derived cofactors are reported. Heinemann and colleagues published their study in Archives of Biochemistry...

Article: Data on biochemistry described by researchers at University of Wisconsin.
Chemicals & Chemistry;  March 20, 2009 ;     246 words ......is part of the catalytic machinery, its presence provides evidence that ThiC employs free radical chemistry as expected for radical SAM enzymes. Martinezgomez and colleagues published the results of their research in Biochemistry (Reaction of AdoMet with ThiC...

Article: `TO THE ENDS OF THE EARTH' DEMANDS PATIENCE, FOR STORY IF NOT JOURNEY.(U)
Daily News (Los Angeles, CA);  October 22, 2006 ;     444 words ......the night and nearly faces down doom with an errant ice floe. Those sharing passage with Edmund include Prettiman, a verbose radical (Sam Neill); a pragmatic if luckless governess (Victoria Hamilton); a troubled parson (Daniel Evans); blustery artist Brocklebank...

Article: Television Their hearts wide open
The Sunday Telegraph London;  July 10, 2005 ;     700+ words ......Jared Harris in Klaus Kinski mode), a frolicsome minx (Paula Jennings as a younger, taller Barbara Windsor-figure), a noisome radical (Sam Neill, having fun as he tries to disprove superstition and shoot an albatross) and Parson Colley (Daniel Evans), who embraces...

Article: The pyrroloquinoline quinone biosynthesis pathway revisited: A structural approach.(Research article)
BMC Biochemistry;  March 27, 2008 ;     700+ words ......pathway with significant sequence similarity (score -64, 16% sequence identity to Molybdenum cofactor biosynthesis protein A) to radical SAM proteins capable of catalysing C-C bond formation. After this reaction the now covalently linked amino acids Glu and Tyr are...