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Article: Marginal Biotin Deficiency is Common in Normal Human Pregnancy and Is Highly Teratogenic in Mice1-3
- Article from:
- The Journal of Nutrition
- Article date:
- January 1, 2009
- Author:
CopyrightCopyright American Institute of Nutrition Jan 2009. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
In studies of marginal biotin deficiency induced experimentally in adults, increased urinary excretion of 3-hydroxyisovaleric acid (3HIA), which likely reflects decreased activity of the biotin-dependent enzyme β-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase (PCC) in peripheral blood lymphocytes have been validated as indices of biotin status. About half of pregnant women excrete increased amounts of urinary 3HIA. However, interpretation of urinary 3HIA excretion rates is problematic, because renal function is altered by pregnancy per se. In a recent pilot study, activity of PCC in peripheral blood lymphocytes ...