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Article: Ciclosporin/colchicine interaction: Colchicine toxicity: case report
- Article from:
- Reactions Weekly
- Article date:
- January 3, 2009
- Author:
CopyrightCopyright Wolters Kluwer Health Adis International Jan 3, 2009. Provided by ProQuest LLC. (Hide copyright information)
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A 60-year-old heart transplant recipient with chronic renal failure who was receiving ciclosporin immunosuppression, developed colchicine-induced toxicity after starting colchicine for suspected gout.
The man, who had undergone heart transplantation about eight years earlier, started dialysis because of progressive renal failure possibly due to calcineurin inhibitor use; his medications included ciclosporin 175 mg/day [duration of treatment not clearly stated]. Three days later, he started colchicine 1 mg/day and, within 3 days, he developed diarrhoea, vomiting, a mild fever (37.6°C), muscle pain and asthenia. During the next 2 days, he developed tachycardia (140 beats/min), dyspnoea, ...