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Article: Clinical and Genetic Description of a Family With a High Prevalence of Autosomal Dominant Restless Legs Syndrome
- Article from:
- Mayo Clinic Proceedings
- Article date:
- February 1, 2009
- Author:
CopyrightCopyright Mayo Foundation for Medical Education and Research Feb 2009. Provided by ProQuest LLC. (Hide copyright information)
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OBJECTIVE: To conduct clinical and molecular genetic analyses of the members of an extended family in Central Indiana with a high prevalence of restless legs syndrome (RLS).
PARTICIPANTS AND METHODS: From February 1, 2006, through August 31, 2008, we collected data from members of this family, which is of English descent. Genealogical methods were used to expand the family tree, and family members were screened with an RLS questionnaire. Telephone Interviews and personal examinations were performed at Mayo Clinic and during a field trip to Central Indiana. Blood samples were collected for molecular genetic analysis. A follow-up telephone Interview was conducted 1 year later.
RESULTS: The ...