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Article: Antineoplastics: Leucoencephalopathy (first report for topotecan, clofarabine and muromonab CD3), transverse myelopathy and peripheral neuropathy in paediatric patients: 4 case reports
- Article from:
- Reactions Weekly
- Article date:
- January 10, 2009
- Author:
CopyrightCopyright Wolters Kluwer Health Adis International Jan 10, 2009. Provided by ProQuest LLC. (Hide copyright information)
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Four patients aged 12-15 years old developed leucoencephalopathy, transverse myelopathy and peripheral neuropathy, following treatment with antineoplastics [dosages not stated] for acute lymphoblastic leukaemia (patients 1, 2 and 4) and Ewing's sarcoma (patient 3).
Patient 1, a 13-year-old boy, received etoposide, cytarabine, vincristine, dexamethasone and intrathecal methotrexate for disease relapse. After 2 months, he experienced left leg weakness progressing to complete paraplegia over 2 weeks. He lost vibration and proprioception up to his pelvis. The last doses of vincristine and methotrexate were 5 and 15 days before symptom onset, respectively. MRI scan findings over 10 months were ...