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Article: The nsdC Gene Encoding a Putative C^sub 2^H^sub 2^-Type Transcription Factor Is a Key Activator of Sexual Development in Aspergillus nidulans
- Article from:
- Genetics
- Article date:
- July 1, 2009
- Author:
CopyrightCopyright Genetics Society of America Jul 2009. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
The formation of the Aspergillus nidulans fruiting body is affected by a number of genetic and environmental factors. Here, the nsdC (never in sexual development) gene-encoding a putative transcription factor carrying a novel type of zinc-finger DNA-binding domain consisting of two C^sub 2^H^sub 2^'s and a C^sub 2^HC motif that are highly conserved in most fungi but not in plants or animals-was investigated. Two distinct transcripts of 2.6 and 3.0 kb were generated from nsdC. The 2.6-kb mRNA accumulated differentially in various stages of growth and development, while the level of the 3.0-kb mRNA remained relatively constant throughout the life cycle. While the deletion of nsdC ...