Article: Patent No. 7,569,575 Issued on Aug. 4, Assigned to Santaris Pharma for Locked Nucleic Acid Derivative Synthesis Strategy (Danish, British Inventors)

Article: Locked nucleic acid antisense ...
Gene Therapy Weekly;  April 17, 2003 ;     603 words ... ... amp; NewsRx.net) -- Locked nucleic acid antisense oligonucleotides ... research from Netherlands, "locked nucleic acids (LNA) are novel high ... biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides ...

Article: Santaris presents on new LNA candidates.(Locked ...
Pharma Marketletter;  October 27, 2008 ;     700+ words ... ... targeted therapeutic candidates developed with its Locked Nucleic Acid technology platform at the Oligonucleotide Therapeutics ... this week underscore the value that our proprietary Locked Nucleic Acid technology holds for bringing antisense back to the ...

Article: WIPO: Inventor in California Develops Double-Stranded ...
US Fed News Service, Including US State News;  September 22, 2008 ;     401 words ... ... Diego, Calif., has developed double-stranded locked nucleic acid compositions. According to an abstract posted by ... the present invention relates to double-stranded locked nucleic acid compositions. The nucleic acids may comprise dsribonucleic ...

Article: LightTyper Assay with ...
Clinical Chemistry;  August 1, 2005 ;     700+ words ... ... assay for genotyping of A896G and C1196T by use of locked-nucleic-acid (LNA)-modified SimpleProbe oligomers (8) on ... genotyping of the samples (Table 1). LNA is a novel nucleic acid analog containing a 2'-4'-bridged ribose that ...

Article: U.S. Genomics Licenses Locked Nucleic Acid ...
PR Newswire;  April 14, 2004 ;     700+ words ... ... worldwide license agreement to incorporate Exiqon's Locked Nucleic Acid (LNA(TM)) chemistries into reagent kits for ... sensitivity, specificity and discriminatory power to nucleic acid recognition assays in a format fully compatible with ...

Article: Locked Nucleic Acid-Enhanced Detection of ...
Clinical Chemistry;  November 1, 2004 ;     700+ words ... ... binding because of high content of weak bases (80% AT). The substitution of 7 of 13 thymidine nucleotides by locked nucleic acid (LNA) derivatives (12) in the sensor probe enhanced the sensitivity and allowed the analysis to be performed ...

Article: Combined Locked Nucleic Acid and Molecular ...
Clinical Chemistry;  July 1, 2006 ;     700+ words ...To the Editor: We developed a quantitative and very sensitive method that combines molecular beacon (1) and locked nucleic acid (LNA) technologies (2) in a single sealed tube. We used the oncogenic somatic JAK2^sup V617F^ single ...