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Article: Mast cells play key role in bacterial infection defense
- Article from:
- Dermatology Times
- Article date:
- September 1, 2002
- Author:
CopyrightCopyright Advanstar Communications, Inc. Sep 2002. Provided by ProQuest LLC. (Hide copyright information)
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CLINICAL DERMATOLOGY
Research shows mammalian mast cells produce and secrete antimicrobial peptide to help cells fight bacterial infections
Los Angeles - Mast cells are directly involved in innate defense against bacterial infection through the synthesis of antimicrobial peptides, according to research presented at the annual meeting of the Society for Investigative dermatology.
Mast cells are known to be key players in the inflammatory response, by synthesis and release of cytokines such as TNF-alfa and IL-4, and are also critical in immune response, particularly in allergy. The research presented showed for the first time that mammalian mast cells produce and secrete an antimicrobial ...