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Article: Cholinergic influence on memory stages: A study on scopolamine amnesic mice
- Article from:
- Indian Journal of Pharmacology
- Article date:
- September 1, 2009
- Author:
CopyrightCopyright Medknow Publications & Media Pvt. Ltd. Sep/Oct 2009. Provided by ProQuest LLC. (Hide copyright information)
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Introduction
Based on experimental and clinical evidences, acetylcholine (ACh) is considered the most important neurotransmitter involved in regulation of cognitive functions. [1],[2] Alzheimer's disease (AD) is the most common age related neurodegenerative disorder characterized by cognitive dysfunction with memory impairment and behavioral disturbances. [3],[4] Besides the neuropathological hallmarks of the disease, neurofibrillary tangles and neuritic plaques, AD is characterized by a consistent deficit in cholinergic neurotransmission particularly in basal forebrain. The therapeutic strategies to combat miseries of cognitive disorder have been aimed to improve ACh activity. Therefore, ...
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