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Article: An adjuvant-free mouse model to evaluate the allergenicity of milk whey protein
- Article from:
- Journal of Dairy Science
- Article date:
- October 1, 2009
- Author:
CopyrightCopyright American Dairy Science Association Oct 2009. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Milk allergy is the most common type of food allergy in humans with the potential for fatality. An adjuvantfree mouse model would be highly desirable as a preclinical research tool to develop novel hypoallergenic or nonallergenic milk products. Here we describe an adjuvant-free mouse model of milk allergy that uses transdermal sensitization followed by oral challenge with milk protein. Groups of BALB/c mice were exposed to milk whey protein via a transdermal route, without adjuvant. Systemic IgGl and IgE antibody responses to transdermal exposure as well as systemic anaphylaxis and hypothermia response to oral protein challenge were studied. Transdermal exposure resulted in a time- ...
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