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Intramembrane electrostatic interactions destabilize lipid vesicles
- Article from:
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Biophysical Journal
- Article date:
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October 1, 2002
- Author:
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Copyright informationCopyright Biophysical Society Oct 2002. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT Membrane stability is of central concern in many biology and biotechnology processes. It has been suggested that intramembrane electrostatic interactions play a key role in membrane stability. However, due primarily to a lack of supporting experimental evidence, they are not commonly considered in mechanical analyses of lipid membranes. In this paper, we use the micropipette aspiration technique to characterize the elastic moduli and critical tensions of lipid vesicles with varying surface charge. Charge was induced by doping neutral phosphatidylcholine vesicles with anionic lipids phosphatidylglycerol and phosphatidic acid. Measurements were taken in potassium chloride (moderate ...
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