Articles > Journals > Health journals > The Journal of Nutrition articles > November 1997

Article: Dietary L-histidine regulates murine skin levels of trans-urocanic acid, an immune-regulating photoreceptor, with an unanticipated modulation: Potential relevance to skin cancer

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The Journal of Nutrition
Article date:
November 1, 1997
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Dietary L-Histidine Regulates Murine Skin Levels of Trans-Urocanic Acid, an Immune-Regulating Photoreceptor, with an Unanticipated Modulation: Potential Relevance to Skin Cancer1,2

Edward C. De Fabo,3 Lindsay J. Webber, Edward A. Ulman* and Lyle D. Broemeling^

ABSTRACT Solar ultraviolet-B radiation (UVB; 290-320 nm) causes skin cancer and suppresses cell-mediated immunity, preventing the rejection of UV-induced tumors. One mechanism initiating UV suppression involves the trans to cis photoisomerization of urocanic acid (UCA), a histidine derivative found in the stratum corneum. The addition of L-histidine to nonpurified mouse diet has been shown to increase skin trans-UCA levels and ...

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