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Article: Ascorbic acid deficiency decreases the renal level of kidney fatty acid-binding protein by lowering the (alpha 2U)-globulin gene expression in liver in scurvy-prone ODS rats
- Article from:
- The Journal of Nutrition
- Article date:
- November 1, 1997
- Author:
CopyrightCopyright American Institute of Nutrition Nov 1997. Provided by ProQuest LLC. (Hide copyright information)
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Ascorbic Acid Deficiency Decreases the Renal Level of Kidney Fatty AcidBinding Protein by Lowering the alpha^sub 2u^-Globulin Gene Expression in Liver in Scurvy-Prone ODS Rats1,2
Saiko Ikeda, Masaharu Takasu, Tsukasa Matsuda,* Atsushi Kakinuma and Fumihiko Horio3
ABSTRACT The evidence for the role of ascorbic acid in gene expression or protein synthesis in vivo is limited. To investigate this role of ascorbic acid, we surveyed proteins whose tissue levels are changed by ascorbic acid deficiency by using ODS rats with a hereditary defect in ascorbic acid biosynthesis. Male ODS rats (7 wk old, body weight ~130 g) were fed a basal diet containing ascorbic acid (300 mg/kg diet) or an ascorbic ...