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Saturated anionic phospholipids enhance transdermal transport by electroporation
- Article from:
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Biophysical Journal
- Article date:
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October 1, 2002
- Author:
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Copyright informationCopyright Biophysical Society Oct 2002. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT Anionic phospholipids, but not cationic or neutral phospholipids, were found to enhance the transdermal transport of molecules by electroporation. When added as liposomes to the milieus of water-soluble molecules to be delivered through the epidermis of porcine skin by electroporation, these phospholipids enhance, by one to two orders of magnitude, the transdermal flux. Encapsulation of molecules in liposomes is not necessary. Dimyristoylphosphatidylserine (DMPS), phosphatidylserine from bovine brain (brain-PS), dioleoylphosphatidylserine (DOPS), and dioleoylphosphatidylglycerol (DOPG) were used to test factors affecting the potency of anionic lipid transport enhancers. DMPS with ...
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