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Article: Electrocochleographic evaluation of the guinea pig model of endolymphatic hydrops
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- November 1, 1997
- Author:
CopyrightCopyright Annals Publishing Company Nov 1997. Provided by ProQuest LLC. (Hide copyright information)
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Electrocochleography (ECochG) was used to evaluate cochlear function in guinea pigs with experimentally induced endolymphatic hydrops (ELH) before and after osmotic dehydration with either glycerol or urea. We surgically induced ELH in the right ears of 9 guinea pigs, while the right ears of 6 guinea pigs received a sham operation. The left ears of the IS animals constituted the normal group. Eight weeks after surgery, summating potential (SP) and action potential (AP) amplitudes were measured prior to and following the administration of glycerol or urea. The SPs and SP/AP ratios were reduced in all groups, with no significant differences among groups or between dehydrating agents. Some of ...
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