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Article: Cardiac sympathetic neuropathy and effects of aldose reductase inhibitor in streptozotocin-induced diabetic rats
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- November 1, 1997
- Author:
CopyrightCopyright Society of Nuclear Medicine Nov 1997. Provided by ProQuest LLC. (Hide copyright information)
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Cardiac autonomic neuropathy can be a cause of sudden death in patients with diabetes mellitus. Clinical evaluation methods for diabetic cardiac sympathetic neuropathy have not been established. Using 1251-metaiodobenzylguanidine (MIBG) and streptozotocin (STZ)-induced diabetic rats, we evaluated cardiac sympathetic neuropathy and the effects of aldose reductase inhibitor (ARI).
Methods: Myocardial MIBG uptake was measured 4 hr after injection in the following groups: control rats, rats treated with insulin or ARI (epalrestat, 100 mg/kg/day) from immediately to 4 wk after STZ injection and rats treated with insulin or ARI from 48 wk. Myocardial MIBG distribution and norepinephrine content ...